Acid Ursodeoxycholic: faatonuga mo le faaaogāina, analogs, iloiloga

Talu ai nei, mo le togafitia o manuʻa eseese ate ua faateleina le faaaogaina acid ursodeoxycholic. Faatonuga mo le faaaogaina o le lotoa vailaau e faailoa lona aoga i le tele o faamai ogaoga. O le a lenei mea? O le a acid ursodeoxycholic? O a oloa o le taimi nei?

faʻamatalaga

acid Ursodeoxycholic, o le faaaogaina o lea ua faavae i luga o lona tupuaga ma meatotino, o se efuefu crystalline papaʻe samasama. O loo i ai se tofo oona. Lenei mea i se tino o le tagata faagaoioia masani ua tuuina atu i le aofaiga laiti. O lona kalave faapitoa e uiga i le 5% le mamafa o le acids atoa bile. O hydrophilic ma e leai se cytotoxicity. o soluble lenei lotoa vailaau i le ava malosi ma acid acetic glacial, teisi soluble i chloroform ma toetoe lava insoluble i le vai. e le o aofia ai acid Ursodeoxycholic i le oloa. E na maua i le tagāmimi oona o le urosa enaena.

acid Ursodeoxycholic (UDCA) o se epimer o acid chenodeoxycholic. Le taimi muamua sa faaaogaina mo le togafitia o reflux gastritis ma gallstones vaeluaina. Le aluga o taimi, sa amata ona faaaoga, ma i le tele o isi maʻi. manatu UDKH sili ona saogalemu o acids bile.

Taunuuga o le acid ursodeoxycholic

Ina ia aso, o le faaaogaina UDKH o se tulaga faatonuina o togafitiga mo maʻi ate cholestatic eseese faatasi ai ma se vaega autoimmune. O le faiga o le faatinoga o lenei sui o le faamautuina o le sela o le tino. e mafai ona tuufaatasia faaletulafono ona molecules i le membranes o sela ate - hepatocytes. Ona o lenei mea e mafai ona latou faia i latou e sili atu e tetee atu itu matautia. O lenei hepatoprotective sooupu ei ai se aafiaga choleretic. UDKH faaitiitia tuufaatasia cholesterol i le ate ma taofia ai lona aafiaga i totonu o le suʻia ai. O lenei fualaau ua maualalo ai ma toe faatuina le mataupu acid bile lithogenicity ai. E faaleleia ai le gaoioiga o lipase, pancreatic ma secretion gastric. acid Ursodeoxycholic ei ai se aafiaga hypoglycemic ma uunaʻia le faavaeina ma le vavaeeseina o bile, e faaitiitia cholesterol.

O lenei fualaau faasaina fiafia cleavage vaega po o le atoatoa o maa cholesterol. O le mafuaaga lena e masani ona sili atu faaaogaina. Fesootai ma le cholesterol, e faateleina ai le solubility o lona taʻega tioata, lea e galue deleteriously i gallstones. ei ai gaoioiga immunomodulating UDKH lea o le a faateleina le gaoioiga lymphocyte, faaitiitia le faaalia o le eseese antigens i le membranes o hepatocytes. E aafia ai le aofai o T-lymphocytes, faaitiitia le aofai o eosinophils.

faaitiitia UDKH le faasalaga o le cholesterol i bile i ona faataapeapega ma le suiga o le vailaau i se vaega tioata suavaia. E aafia ai le faasalalauina enterohepatic o masima bile. O se taunuuga o lenei faaitiitia reabsorption i le gāʻau o tuufaatasi hydrophobic ma oona endogenous. O lenei fualaau faasaina ei ai se hepatoprotective tuusao ma le aafiaga choleretic. acid Ursodeoxycholic, mai lea iloiloina o le tomai faapitoa i hepatology faaalia lona aoga, e mafai ona faaitiitia cystic ate i lona tulaga soloitua puta.

talosaga

acid Ursodeoxycholic, lea talosaga ua faia i lalo o le vaavaaiga a le ua tofia auai fomai i ia tuutuuga e pathological:

• luma o le maa cholesterol faasa i le gallbladder po o amioga masani;

• le mafai ona tausia endoscopically po o taotoga;

• faaumiumi, atypical, ma matuitui hepatitis autoimmune ;

• luma o le maa cholesterol ina ua uma masini ma extracorporeal lithotripsy;

• oona (o fualaau faasaina, ava malosi), faaleagaina ate;

• sclerosing cholangitis;

• cirrhosis biliary autu, faatasi ai ma se faailoga o decompensation;

• atresia, tamaitusi biliary;

• cystic fibrosis;

• hepatitis toaaga faaumiumi;

• cholestasis i le taimi o meaai paleni parenteral;

• dyskinesia biliary;

• syndrome dyspeptic biliary ma dyskinesia biliary ma holetsistopatii;

• opistorhoze faaumiumi;

• atresia biliary congenital;

• esophagitis reflux biliary ma reflux gastritis.

acid Ursodeoxycholic (UDKH) faaaoga mo puipuiga o ate faaleagaina faaōleōle e pulega o cytostatics ma contraceptives hormonal. E faatonuina mo le isi faamai e mafua mai i stagnation o bile. tofia UDKH mo togafitiga adjuvant i ate transplantation po o isi okeni.

Contraindications

acid Ursodeoxycholic, lea e iloiloina le vaega sili ona lelei, ei ai contraindications matuia. E aofia ai:

• faamai inflammatory o le au tagāmimi, loto ona ma ducts bile i le vaega matuitui;

• rentgenopolozhitelnye gallstones ma faamalieina maualuga kalisiu;

• faalavelaveina o le tamaitusi biliary;

• hypersensitivity;

• cirrhosis i decompensation;

• faamaʻi a Crohn;

• folafola faaletonu i le faagaoioiga o le pancreas, ate ma fatugaʻo.

tapulaa o faaaogaina

acid Ursodeoxycholic, faatonuga mo le faaaogaina lea manino faailoa mai le leai o tapulaa tausisi i ana talosaga, e le tofia pepe e oo atu i le 3 tausaga i se faiga pusa gafa. Mo lo latou faaaogaina le taulimaina o se slurry aofia ai lenei mea o fualaau faasaina. Seia oo i le taimi nei, e le i faia atamamai suesuega talafeagai faamoemoe i le fuafuaina o le aafiaga o lenei cholelitolitic mea e faalagolago i le matua o le tamaitiiti. I le taimi lava e tasi, suesuega faia i luma o le fanau i atresia biliary ma faamai nisi ate te leʻi faaalia faafitauli o tamaiti patino.

Sauniuniga o loo acid ursodeoxycholic, na tuuina mai e maitaga fafine pe a le aafiaga faamoemoe o togafitiga ma e sili lenei sooupu nai lo le tulaga lamatia gafatia e le tamaitiiti e leʻi fananau mai. E le tatau ona galo ia i le suesuega atoa faasaienisi o le saogalemu vailaau mo lenei vaega o le gasegase o loo faaaluina e leai se tasi. Talu ai e le o iloa pe ati UDKH i le susu o le susu, e manaomia le lapataiga i le tofiga o le fualaau faasaina i tamaitai faatausimai.

itu aafiaga

acid Ursodeoxycholic, faatonuga mo le faaaogaina lea e faailoa mai e le gata o le tapulaa i totonu o ana talosaga, ae faapea foi i aafiaga e mafai itu, e mafai ona taitai atu ai i ofoofogia pathological e pei o:

• manava masuasua, manavatatā;

• faafaufau;

• faateleina transaminases;

• tiga i le quadrant pito i luga tauagavale ma itulagi epigastric;

• allergic tali paʻu (itching, mageso);

• maa calcining.

Togafitiga o cirrhosis biliary autu nisi taimi lenei sauniuniga mafua ei decompensation tumau le onosai, mou atu ina ua uma ona aveesea le mauaina o lenei fualaau faasaina.

faiga o lapataiga tau puipuiga

Ia manuia le litholysis manaomia maa cholesterol faaaogaina UDKH ina ia amanaia ai le tulaga e faapea:

• e le o sili atu lo latou toatele nai lo 2 cm;

• latou te le tuuina atu paolo i luga o le radiograph;

• gallbladder ua faagaoioia e masani;

• ducts faatumauina patency;

• se puta faatumulia i maa itiiti ifo i le afa;

• E le o loo i ai amioga bile masani maa.

O a isi tapulaa i luga o le ulufale o acid ursodeoxycholic? Faatonuga i lenei sauniuniga faafomai faailoa mai e faapea o le togafitiga mo se taimi umi, e sili atu i le masina e 1, e tatau ona aunoa (1 30 aso uma) e faatautaia ai le mataituina o transaminases hepatic, phosphatase, bilirubin, gamma-glutamyl toto transferase. E matua taua tele le Taitaia o sea iloiloga i le uluai 3 masina o togafitiga i UDKH. O le lelei o togafitiga ua faamauina e X-ray ono masina uma ma bile ultrasound. Mo le puipuiga o le toe faiga o le faoa faaauau pea ona cholelithiasis togafitiga ma ina ua mavae faataapeina atoatoa o maa. E mafai ona ave le tele o masina.

Taimi o le togafitiga UDKH tamaitai o le fanauina o fanau ua fautuaina matua e faaaoga metotia faatuatuaina o le puipuiga e faasaga i maitaga. Atonu o fualaau faasaina lē hormonal po contraceptives o loo i aofaiga itiiti o estrogen.

ua Faamatuu ma inumaga

acid Ursodeoxycholic, lea tusi o faatonuga e tuuina se faamatalaga auiliili o lona circuitry taliaina, ua gaosia i ituaiga inumaga e pei:

• pusa o gafa ma papa o le 150 ma le 250 mg;

• taofia lē tumau mo tamaiti.

matua faatulaga taitoatasi inumaga UDCA. E faalagolago lea i le ogaoga o le tulaga o le tagata ma lona mamafa tino. I le tele o tulaga, ua faatonuina e 10-20 mg / kg i le aso. O lenei inumaga ua aveina i se tasi taimi, i le afiafi. Le umi o togafitiga e faalagolago i le molimau. ua mitiia lenei fualaau faasaina i totonu o le tamai suʻia ai, ma ina ua mavae 3 itula ua matauina le plasma mo lona faasalaga aupito maualuga. medicaments taliaina Tumau o loo acid ursodeoxycholic, ua faia ai le acid bile autu i le tino o le tagata. na pulea lenei mea i le tele o suiga ma o le taunuuga o galuega faatino mulimuli pei metabolites i feces ma miaga.

Umi o le vaitaimi o togafitiga ua fuafuaina e le fomai auai. E mafai ona eseese e fuafua lava i le ituaiga o faamai. I nisi o tulaga ogaoga, le umi o le taliaina fualaau faasaina UDKH mo ni tausaga.

Fegalegaleaiga ma isi fualaau faasaina

I se mauaina faatasi ma UDKH "Cyclosporine" faateleina le mautinoa o le mitiia o le gata. I le faateleina manino plasma le faasalaga o sauniuniga faafomai. I tulaga e le masani le taliaina UDKH le taimi e tasi i le sauniuniga "Ciprofloxacin" faaitiitia o faasalaga mulimuli.

acid Ursodeoxycholic (analogues)

acid Ursodeoxycholic (pusa o gafa, papa) gaosia i lalo o igoa eseese. O sui eseese excipients ulu atu io latou tuufaatasiga. O lea la, o le maketi e mafai ona ausia nei fualaau faasaina ma acid ursodeoxycholic:

• pusa o gafa "Ursosan" tofia mo le togafitia o faasalalauina faamai o le ate, cholelithiasis, ma gastritis reflux biliary ma reflux esophagitis, cirrhosis autu, fualaau faasaina ma oona faaleagaina ate, cholecystectomy, ava malosi, sclerosing cholangitis, Biliary atresia, nonalcoholic steatohepatitis. acid Ursodeoxycholic ( "Ursosan") e faaaogā mo le puipuia o manuʻa ate.

• papa "Ukrliv" o le ave i le faaletonu o hepatic, hepatitis faaumiumi, cholelithiasis.

• pusa o gafa "Ursofalk" filifilia mo eseese faamai o le gallbladder ma le ate, tuuina atu faatasi ma cholestasis, a faaitiitia o nisi galuega tauave ate, tulaga siitia cholesterol. E aofia ai cirrhosis biliary autu ma sclerosing cholangitis, reflux gastritis ma reflux esophagitis, hepatitis o etiology eseese, o maa cholesterol, cystic fibrosis, le tele o manuʻa o le ate, stasis bile. O lenei sauniuniga e faaaogaina o se prophylactic mai i manuʻa ate pe mauaina fualaau faasaina malosi.

• papa "Ursodeks" e ave i cirrhosis biliary aunoa auga decompensation ma reflux gastritis. o loo faaaogaina e faataapeina maa laiti cholesterol i le faagaoioiga masani o le tagāmimi oona.

• pusa o gafa "Ursodez" faaaogaina e solia i lalo maa cholesterol, o le togafitiga o reflux gastritis, mo le togafitiga symptomatic mo cirrhosis autu o le ate ma e leai ni faailoga o decompensation.

• pusa o gafa "Ursolizin" ua filifilia mo le faataapeina o maa cholesterol, ma togafitiga symptomatic o cirrhosis biliary, gallbladder cholesterosis ma reflux gastritis. ua faaaoga e le fualaau faasaina i le togafitiga faigata mo le gasegase ma faaumiumi hepatitis ma cirrhosis.

• pusa o gafa "Choludexan" faaaogaina mo le togafitia o cholelithiasis uncomplicated, hepatitis toaaga faaumiumi, ava malosi ma manuʻa oona ate, nonalcoholic steatohepatitis, cirrhosis biliary autu, autu sclerosing cholangitis, cystic fibrosis, dyskinesia biliary, reflux gastritis ma reflux esophagitis.

• pusa o gafa "Urdoksa" ua faatonuina i totonu o cirrhosis biliary autu, faatasi ai ma se faailoga o decompensation, gastritis reflux. O le fualaau faasaina sa lelei faaleaogaina le laiti ma auala maa cholesterol, ao tumau pea le galuega tauave masani o le tagāmimi oona.

• pusa o gafa "Autu poo le C", tofia i cholelithiasis uncomplicated, cirrhosis autu, matuitui ma hepatitis faaumiumi, sclerosing cholangitis, atresia tamaitusi intrahepatic, reflux gastritis ma reflux esophagitis, cholestasis, i le taimi o meaai paleni parenteral, dyskinesia biliary, ate faamaʻi, ma cystic fibrosis, gepatoze gaʻo, syndromes dyspeptic. O le sauniuniga o loo faaaogaina mo le puipuiga o le ate faaleagaina i le faaaogaina o contraceptives hormonal ma cytostatics, faavaeina maa i obesity.

acid Ursodeoxycholic, analogs o lenei mea o loo faia na faatonuina e se fomai.